Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on Alveolar Recruitment and Distension by CT-scan in Early ARDS Patients

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Unknown

Conditions: ARDS

Treatments: Device: High frequency percussive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02885584

2013-A00465-40 (Other Identifier)

2013-11

Details and patient eligibility

About

High frequency percussive ventilation (HFPV) is a high frequency ventilation mode in which high frequency pulses accumulate to generate a low frequency tidal volume at a controlled airway pressure. Previous studies have suggested a protective effect of HFPV on lung injury. The goal of our study is to compare, in early ARDS patients, the effects of conventional mechanical ventilation and of high frequency percussive ventilation on alveolar recruitment and distension evaluated by CT-scan

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient undergoing invasive ventilation for more than 24h
• ARDS patient

Exclusion criteria

• Pneumothorax drained or not
• Patient undergoing extracorporel mechanical oxygenation
• Patient who had a pneumonectomy partiel or total

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Transpulmonary pressure controlled mechanical ventilation

Experimental group

Description:

transpulmonary pressure will be used for ventilation settings

Treatment:

Device: High frequency percussive ventilation

Conventional pressure-controlled mechanical ventilation

No Intervention group

Description:

transpulmonary pressure will not be used for ventilation settings