Cooperative Adenomyosis Network (CAN)

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Metrorrhagia; Ultrasonography; Dysmenorrhea; Radiography; Pathology; Infertility, Female

Study type: Observational

Funder types: Other

Identifiers

NCT03230994

CAN201706

Details and patient eligibility

About

To set up a Cooperative Network by enrolling 5000 patients with Adenomyosis(AM) from multiple centers.Based on the Network platform and Database,the investigators try to explore the diagnostic strategies for AM and carry out epidemiological survey on the semeiology of AM.In addiction，the investigators expect to conduct research on the effect and the follow-up fertility outcomes of different medical or surgical treatment, the etiology of AM and endometriosis,the perspective investigation of the malignant transformation of AM ;the high-risk factors of AM,and finally propel the formation of Expert Consensus and Clinical Guidelines about AM which suitable to chinese conditions.

Full description

5000 women diagnosed of Adenomyosis(AM) with pathology, transvaginal ultrasonography or magnetic resonance image（MRI）will be enrolled from nationwide multicenters. The investigators would build up Network platform, and database with the registered data within 6 months. 30-month follow-up with an interval of at least once every 6 months will be done for every patient ，and update the database timely.

Based on the Network platform and Database,we try to explore the diagnostic strategies for AM and carry out epidemiological survey on the semeiology of AM.In addiction，the investigators expect to conduct research on the effect and the follow-up fertility outcomes of different medical or surgical treatment,the etiology of AM and endometriosis,the perspective investigation of the malignant transformation of AM ;the high-risk factors of AM,and finally propel the formation of Expert Consensus and Clinical Guidelines about AM which suitable to chinese conditions.

Enrollment: 5,000 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women diagnosed of adenomyosis by pathology, transvaginal ultrasound or MRI.

Exclusion criteria

• Refusal to join the study

Trial design

5,000 participants in 1 patient group

Different Treatment Groups

Description:

Women would receive different pharmacotherapy from the standard approach，such as levonorgestrel-releasing intrauterine system(LNG-IUS)，Gonadotrophin releasing hormone agonist(GnRH-a),surgery,etc.