COPD and Inflammatory Mediators

Faculty of Medicine, Sousse

Status

Unknown

Conditions

COPD

Treatments

Other: exercise training

Study type

Interventional

Funder types

Other

Identifiers

NCT04271124

Effect of exercise training

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020.

Full description

COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversible.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also many others factors such as genetics and cigarette smoking. Cigarettes are harmful and contribute to different extra pulmonary disorders. Although COPD affects lungs some extrapulmonary manifestations are prescribed such as muscle dysfunction, abnormal respiratory muscles and systemic inflammation. Indeed, the systemic inflammation[6, 8] is considered as a key process in the pathogenesis of COPD. It involves different cells and molecules; high levels of circulating of white blood cells, increased plasma c-reactive proteins (CRP), interleukin 6 (Il6) have been reported in.those patients.Likewise, systemic inflammation could worsen the comorbidities (cardiovascular, osteoporosis..) and may lead to the exercise limitation.

Enrollment

40 estimated patients

Sex

Male

Ages

50 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

COPD diagnosed by pulmonary function testing
Clinically stable
Abscence of other obstructive diseases
Signed written consent

Exclusion criteria

Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions
cardiovascular diseases.
Contre-indications to physical therapy
Acute exacerbations a month before the intervention