COPD Circuit Exercise

Texas A&M University

Status

Unknown

Conditions

Residual Symptoms of COVID 19

Covid19

COPD

OSA

Treatments

Behavioral: Exercise (Resistance Training

Study type

Interventional

Funder types

Other

Identifiers

NCT05395390

2019-0149 (Other Identifier)

Details and patient eligibility

About

This study is being done to understand body's response to hybrid home-based and on-site rehabilitation program utilizing individually tailored exercises throughout a total of 18 sessions with 12 of them occurring onsite, in people with and without chronic respiratory diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) and in individuals recovered from COVID-19. Exercise training programs vary widely for people with COPD, OSA, and during prolonged recovery from COVID infection. This study will help identify if this program is helpful to address muscle loss and fatigue specifically in populations with and without chronic respiratory diseases.

Enrollment

200 estimated patients

Sex

All

Ages

30 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Ability to walk, sit down and stand up independently
- Age 30 - 85 years
- Ability to lay in supine or elevated position for up to 3 hours
- Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: FEV1 < 70% of reference FEV1

-or- Obstructive Sleep Apnea (OSA)

-or- 2 weeks post-recovered* from laboratory confirmed case of COVID

● Willingness and ability to comply with the protocol

*Recovered is defined according to Brazos County Health District as someone who has been fever-free for 24 hours without fever-reducing medications, and it has been 10 days after onset of symptoms.

Inclusion criteria control subjects

Healthy male or female according to the investigator's or appointed staff's judgment
Ability to walk, sit down and stand up independently
Age 30 - 85 years
Ability to lay in supine or elevated position for up to 3 hours
No diagnosis of chronic lung disease
Willingness and ability to comply with the protocol

Exclusion criteria

Unable to exercise due to physical limitations (i.e. neuromuscular and/or orthopedic disorders)
- Established diagnosis of malignancy
- Presence of acute illness or metabolically unstable chronic illness
- Presence of fever within the last 3 days.
- Expected to have surgery within 1 month of screening or during exercise training
- Any other condition according to the PI or research staff that was found during the screening visit, that would interfere with the study or safety of the patient.
- Previous injury that could interfere with participation in resistance exercise protocol.
- Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements.
- (Possible) pregnancy.
- Already enrolled in another clinical trial and that clinical trial interferes with participating in this study. When during the period from enrollment to the test day any condition causing the subject to not meet inclusion criteria or to meet exclusion criteria, the subject will be excluded from the study.