COPD in Obese Patients

Voronezh N.N. Burdenko State Medical Academy

Status: Completed

Conditions: Obese; Obesity, Abdominal; Copd

Study type: Observational

Funder types: Other

Identifiers

NCT04105075

YSShkatova

Details and patient eligibility

About

The study included 176 patients with COPD. The first group included 88 normal weight patients with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years. The second group included 88 patients with COPD and obesity: 64 men and 24 women, mean age 62.94 ± 5.96 years. We assessed the frequency of COPD exacerbations in last 12 months, the severity of symptoms such as dyspnea, sputum production, fatigue. Spirometry, six-minute walk test and analysis of body tissue type composition were performed. BODE index was calculated. Levels of leptin, adiponectin, interleukins-4,6,8,10, interferon-γ, c-reactive protein (CRP), tumor necrosis factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor alpha (TNF-α) were measured in blood serum.

Enrollment: 176 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD diagnosis, informed consent for voluntary participation in the study

Exclusion criteria

• patient participation in any interventional study,
• COPD exacerbation,
• concomitant lung diseases, such as confirmed or suspected malignant lung disease or other respiratory disease, such as interstitial pulmonary fibrosis, tuberculosis, sarcoidosis, bronchial asthma, bronchiectasis,
• concomitant diseases of other organs and systems, such as acute cardiovascular diseases, chronic kidney diseases and liver failure.

Trial design

176 participants in 2 patient groups

Patients with COPD and obesity

Description:

Patients consented to have a blood sample taken

Normal body weight patients with COPD

Description:

Patients consented to have a blood sample taken