Copeptin in Normal- to Hyperosmolar States

University Hospital Basel

Status: Completed

Conditions: Copeptin Blood Values

Treatments: Other: Hypertonic saline infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT02647736

CoNorm

Details and patient eligibility

About

Kinetics of Copeptin in response to osmotic alterations in healthy volunteers

Full description

Construction of the standard area of copeptin release in the normo- and hyperosmolar state and its half-life based on ist decline during hypoosmotic Suppression in healthy volunteers.

Enrollment: 90 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Minimum Age 18
• no severe comorbidities
• no medication (except contraceptives)
• baseline sodium Level 135-145mmol/l
• euvolemic status

Exclusion criteria

• history of heart failure
• liver cirrhosis
• kidney disease (GFR <60ml/min)
• anemia
• uncontrolled Hypertension
• pregnancy
• Diabetes mellitus
• BMI >28kg/m2
• other severe disease

Trial design

90 participants in 1 patient group

Copeptin values in normo- to hyperosmolar states

Experimental group

Treatment:

Other: Hypertonic saline infusion