Copeptin in the Differential Diagnosis of Dysnatremia in Hospitalized Patients (COMED)

University Hospital Basel

Status: Completed

Conditions: Hypernatremia; Hyponatremia

Study type: Observational

Funder types: Other

Identifiers

NCT01456533

COMED Study

Details and patient eligibility

About

Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.

Osmotically inadequate secretion of antidiuretic hormone (ADH) is the predominant mechanism in most dysnatremic disorders. ADH measurement is cumbersome. It is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of ADH.

Objective: To evaluate the additional value of copeptin to improve a currently used algorithm in the differential diagnosis of (A) severe hypoosmolar hypo- and (B) severe hypernatremia.

Design: Prospective observational study.

Enrollment: 300 patients

Sex: All

Ages: 18 to 110 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hyponatremia <125 or hypernatremia >155 mmol/L

Exclusion criteria

• no informed consent

Trial design

300 participants in 1 patient group

hospitalized patients

Description:

hospitalized patients with hyponatremia