Copeptin Testing During Pre-hospital Care in the Treatment of Chest Pain Suggestive of Acute Coronary Syndrome (SCA COP)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Chest Pain

Treatments: Biological: Blood work upon arrival in the emergency room; Biological: Blood work at 3 hours post-arrival in the emergency room; Biological: Blood work in the ambulance

Study type: Observational

Funder types: Other

Identifiers

NCT02116426

LOCAL/2013/PGC-01

2013-A01201-44 (Other Identifier)

Details and patient eligibility

About

The main objective of our study is to evaluate the diagnostic value of copeptin testing in association with troponin HS testing during pre-hospital care (ambulance care) in the treatment of patients whose pattern of use is the occurrence chest pain suggestive of ACS but not ST+.

Full description

The secondary objectives of this study are to:

A. Evaluate the diagnostic value of determination of copeptin testing in pre-hospital care in another diagnosis;

B. Assess the prognostic value of copeptin assay on vital prognosis at day 28;

C. Evaluate the kinetics of copeptin and troponin HS between initial ambulance care and arrival at the emergency department;

D. Evaluate the potential impact of copeptin testing on pre-hospital patient care;

E. Assess the economic impact of pre-hospital copeptin testing in terms of hospital stays and optimizing ambulance movements.

Enrollment: 320 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all major adult patients taken in charge by the emergency ambulance services of the participating centers for non-traumatic chest pain for suspected ACS and an electrocardiogram initially excluding an ST segment elevation

Exclusion criteria

• The patient is participating in another study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection, under tutorship or curatorship
• The patient (or a legal representative) formalizes his/her opposition for the study
• It is impossible to correctly inform the patient
• The patient is pregnant, parturient, or breastfeeding
• The patient has a contraindication for a treatment used in this study
• The patient's initial electrocardiogram indicates an ST segment elevation

Trial design

320 participants in 1 patient group

The study population

Description:

The study population includes all adult patients taken in charge by the emergency ambulance services of the participating centers for non-traumatic chest pain for suspected Acute Coronary Syndrome (ACS) without ST segment elevation. Intervention: Blood work in the ambulance Intervention: Blood work upon arrival in the emergency room Intervention: Blood work at 3 hours post-arrival in the emergency room

Treatment:

Biological: Blood work upon arrival in the emergency room

Biological: Blood work at 3 hours post-arrival in the emergency room

Biological: Blood work in the ambulance