Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression

University of Gaziantep

Status: Completed

Conditions: Migraine

Treatments: Genetic: Migraine CNV

Study type: Interventional

Funder types: Other

Identifiers

NCT04912752

2020/12

Details and patient eligibility

About

Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients. The 15q13.3 gain/loss variation in this gene may be associated with migraine.

Full description

Migraine is a common neurological disorder. Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.

Enrollment: 200 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Migraine

Exclusion criteria

Vascular problems

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

200 participants in 2 patient groups

Case-Control

Other group

Description:

Copy number variation

Treatment:

Genetic: Migraine CNV

Case-Control 1

Experimental group

Description:

Gene expression

Treatment:

Genetic: Migraine CNV