CoQ10 in Statin-associated Asthenia

University of Bologna

Status: Completed

Conditions: Physical Performance; Hypercholesterolemia

Treatments: Dietary Supplement: Coenzyme Q10; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06391606

QELD_Stat_2017

Details and patient eligibility

About

This was a double-blind, randomized, placebo-controlled clinical study aiming to assess the effects of supplementation with CoQ10 phytosome on physical performance in older adults with self-reported statin-associated asthenia.

Enrollment: 60 patients

Sex: All

Ages: 65 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 65-80 years of age
• treatment for >6 months with statin monotherapy (i.e. enrolled individuals were asked to be on the same statin at the same dosage for >6 months)
• statin-associated asthenia for >3 months

Exclusion criteria

• serious or disabling diseases (e.g. severe organ failure, malignancy or dementia)
• orthopedic disorders, myopathies and any other acute or chronic disease that could significantly affect the individual's perception of asthenia
• obesity (body mass index (BMI)> 30 Kg/m2)
• known gastrointestinal disorders potentially affecting the absorption of CoQ10

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

Coenzyme Q10

Active Comparator group

Description:

2 pills of 150 mg CoQ10 phytosome (i.e. 300 mg CoQ10 phytosome per day)

Treatment:

Dietary Supplement: Coenzyme Q10

Placebo

Placebo Comparator group

Description:

2 pills of placebo per day

Treatment:

Other: Placebo