Corail Stability at 5-Years Post-Total Hip Arthroplasty

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Status: Completed

Conditions: Total Hip Arthroplasty

Treatments: Other: Standard Post-Operative Clinic Visit; Other: Study-Specific Outcomes

Study type: Observational

Funder types: Other

Identifiers

NCT05893563

13405

Details and patient eligibility

About

Total hip arthroplasty (THA) is the mainstay, definitive management for end-stage hip osteoarthritis. Despite improvements of surgical and patient factors, prosthesis-related complications continue to increase in number. This is contributed to by the greater number of such surgeries being completed, larger proportion of elderly individuals among the population, and younger patient age being offered surgical intervention. Specifically, implant loosening and associated migration, is the pathology most commonly yielding revision surgery. A previous study assessing migration of total hip prostheses found that the greatest degree of migration occurred in the first 2 weeks postoperatively, although implants were considered overall stable 2 year following surgery. Continued evaluation of implant migration at time points further from surgery, specifically at 5 years postoperatively, offers insight into long term complications rates. Assessing implant migration will be completed using various imaging modalities, radiostereometric analysis (RSA) and computed tomography (CT). Comparisons between RSA and CT imaging will allow for greater analysis with regards to characterization of implant migration and associated bony changes. Additionally, an individual's gut microbiome has been shown to correspond to their inflammatory and immune profile. Association between gut microbiome profile and implant migration will be assessed to determine if underlying relationship does exist.

Enrollment: 48 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participated in the originally investigated cohort.
• Minimum of 4-5 years post-operation

Exclusion criteria

• Pregnancy
• Unable to attend follow-up

Trial design

48 participants in 2 patient groups

Direct Anterior

Description:

Patients who underwent the Direct Anterior (DA) surgical approach

Treatment:

Other: Study-Specific Outcomes

Other: Standard Post-Operative Clinic Visit

Direct Lateral

Description:

Patients who underwent the Direct Lateral (DL) surgical approach

Treatment:

Other: Study-Specific Outcomes

Other: Standard Post-Operative Clinic Visit