Cord Blood Microtransplantation for Treatment of Acute Myeloid Leukemia

The Affiliated Hospital of the Chinese Academy of Military Medical Sciences

Status and phase: Enrolling; Phase 1

Conditions: Safety Issues; Efficiency

Treatments: Biological: microtransplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT04174586

CB-001

Details and patient eligibility

About

Discuss the effectiveness and safety of cord blood microtransplantation for treatment of acute myeloid leukemia

Full description

The investigators conducted a prospective, single center clinical trial to dissuss the outcomes and toxicities of HLA-mismatched cord blood infusion after chemotherapy (microtransplantation) in older patients with acute myeloid leukemia (AML)

Enrollment: 20 estimated patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. de novo acute myeloid leukemia
2. age 60-80

Exclusion criteria

1. have no suitable donor or donor refused
2. patient refused to accept donor cells

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

cord blood group

Experimental group

Description:

standard induction and consolidation chemotherapy with cord blood microtransplantation

Treatment:

Biological: microtransplantation