Cord Blood Nesfatin-1 and Irisin in the Intrauterine Growth Restricted Fetuses

Yuzuncu Yıl University

Status: Completed

Conditions: Irisin; Intrauterine Growth Restriction; Nesfatin-1

Treatments: Other: cord blood specimen during the delivery

Study type: Observational

Funder types: Other

Identifiers

NCT03808571

1

Details and patient eligibility

About

: The aim of this study is to investigate Cord blood irisin and nesfatin-1 levels in pregnancies with intrauterine growth retardation and to determine whether they are associated with abnormal fetal doppler findings or not.

Full description

This study was conducted at Yüzüncü Yıl University Medical Faculty Obstetrics and Gynecology Clinic. The study group included 34 pregnant women ranged from 18 to 45 years old who have intrauterine growth retardation and underwent ceseraen section. 32 pregnant women who had no abnormality on prenatal follow-up and underwent elective ceserean seciton served as control group. The maternal age, height, weight, body mass index (BMI), systolic and diastolic blood pressures were recorded in both groups of patients. Maternal serum total blood count and biochemical parameters were obtained from the laboratory parameters. Gestational week at birth, birth weight, sex, 1st and 5th minute APGAR scores were recorded. Blood samples were collected from all the cases during the cesarean section for measurmenet of nesfatin-1 and irisin by doubly clamped umbilical cord. Blood samples were immediately centrifuged in sterile tubes and maintained at -80 ° C until assessed.

Enrollment: 66 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant women with intrauterine grwoth rectricted fetuses.
• Healthy pregnancies

Exclusion criteria

• Pregnant women with chronic medical conditions
• multiple pregnancies
• fetuses with fetal malfomations or genetic syndromes
• pregnant women older than 45 years old

Trial design

66 participants in 2 patient groups

Study group

Description:

Pregnancies complicated with intrauterine growth restricted fetuses

Treatment:

Other: cord blood specimen during the delivery

Control group

Description:

Healthy pregnancies

Treatment:

Other: cord blood specimen during the delivery