Corneal Biomechanics During Pregnancy (CorvisPreg)
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About
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
Full description
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
Measurement of intraocular pressure is highly dependant on corneal properties. With the Corvis ST device by Ocular Inc. it is possible to measure intraocular pressure and investigated corneal biomechanics. The aim of this study is therefore to compare corneal biomechanical properties during the third trimester with corneal biomechanical properties at 3 months after delivery.
Enrollment
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Inclusion criteria
- females
- pregnant
- age 18 to 38 yo
- uncomplicated singleton pregnancy
Exclusion criteria
- any history of ocular disease or surgery other than conjunctivitis, especially no history of glaucoma or corneal disease
- systemic diseases, i.e. diabetes, hypertension, collagenase
- current contact lens wear
- before pregnancy taking any systemic or ocular medications
Trial design
50 participants in 1 patient group
Trial contacts and locations
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Central trial contact
Belgin o Özsoy, MD; Marc o Toeteberg-Harms, MD, FEBO
Data sourced from clinicaltrials.gov
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