Corneal Endothelial Cell Changes After Phacoemulsification in Patients With Type 2 Diabetes Mellitus

Beijing Tsinghua Chang Gung Hospital

Status: Completed

Conditions: Cataract; Diabetes Mellitus

Treatments: Other: specular microscope

Study type: Observational

Funder types: Other

Identifiers

NCT03260673

17102

Details and patient eligibility

About

This study investigate the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.

Full description

The investigators do the clinical prospective study including 30 patients with type 2 diabetes and 30 control patients without diabetes scheduled to undergo cataract surgery. The corneal endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness(CCT) were recorded at baseline and at 3 months postoperatively.Then, the investigators compared the two sets of data. At last observing the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.

Enrollment: 30 patients

Sex: All

Ages: 58 to 86 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

the experimental group:

1. Clinical diagnosis of cataract
2. Type 2 diabetes mellitus
3. The recent blood glucose control was stable
4. The glycosylated hemoglobin < 8%

The control group:

1. Clinical diagnosis of cataract
2. No history of type 2 diabetes

Exclusion criteria

1. Corneal lesions
2. Anterior inflammation
3. Ocular trauma or surgical history
4. Glaucoma
5. Corneal endothelial cell density < 1500 / mm squared

Trial design

30 participants in 2 patient groups

the diabetic group

Description:

patients with type 2 diabetes scheduled to undergo cataract surgery

Treatment:

Other: specular microscope

the control group

Description:

patients without diabetes scheduled to undergo cataract surgery

Treatment:

Other: specular microscope