Corneal Endothelium After Phacoemulsification in Pseudo Exfoliation Syndrome

Minia University

Status: Completed

Conditions: Pseudoexfoliation Syndrome; Corneal Endothelial Cell Loss

Treatments: Procedure: phacoemulsification

Study type: Interventional

Funder types: Other

Identifiers

NCT05447130

PEX2019

Details and patient eligibility

About

To study corneal endothelial cells changes after phacoemulsification in patients with senile cataract and pseudoexfoliation syndrome (PEX) compared with control patients with senile cataract using specular microscope.

Full description

In a prospective interventional case-control study, 20 eyes with cataract and PEX and 20 control eyes with cataract without PXE were subjected to phacoemulsification and posterior chamber foldable intraocular lens implantation in Minia University Hospital and Genaidy Eye Center between March 2019 and December 2020. Specular microscopy was done preoperatively, 3 and 6 months postoperatively. Endothelium cell density (ECD), coefficient variation (CV), hexagonality, pleomorphism and corneal thickness were evaluated and compares between PXE and control eyes.

Enrollment: 40 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• senile cataract age more than 55 years

Exclusion criteria

• PEX with glaucoma, eyes with cornea guttata or any corneal dystrophy, zonular dehiscence, very dense nuclear cataract (cataracta nigra) history of previous ocular surgery.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

40 participants in 2 patient groups

Corneal Endothelial Evaluation after Phacoemulsification in Eyes with Pseudoexfoliation Syndrome

Experimental group

Treatment:

Procedure: phacoemulsification

Corneal Endothelial Evaluation after Phacoemulsification in Eyes without Pseudoexfoliation

Experimental group

Treatment:

Procedure: phacoemulsification