Corneal Endothelium Evaluation After Phacoemulsification in Diabetec and Non-diabetic Patients With Pseudoexfoliation

Minia University

Status: Completed

Conditions: Pseudoexfoliation

Treatments: Procedure: phacoemulsification of the lens

Study type: Interventional

Funder types: Other

Identifiers

NCT04965168

691:11/2020

Details and patient eligibility

About

Our study is a comparative study, that was conducted to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (IOL) implantation in normal controls, in non-diabetic and diabetic patients with PEX, and in patients with PEX only using specular microscopy.

Full description

Our study is a comparative study that included 4 groups (controls, patients with PEX, non-diabetic patients with PEX, diabetic patients with PEX) to evaluate the corneal endothelial cells changes and central corneal thickness after uncomplicated phacoemulsification and intra ocular lens (IOL) implantation using specular microscopy, over a 6 months follow up period.

Enrollment: 61 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Senile cataract with age between 50 to 70 years
• Clear cornea with no zonuler dehiscence
• Lens opacity classification system III (LOCS III), with grade 2-3 nuclear cataract with any additional cortical (C) and posterior sub capsular (P)

Exclusion criteria

• Uncontrolled DM in diabetic groups
• Presence of autoimmune diseases
• Patients with glaucoma
• Corneal guttata
• Zonular dehiscence
• Rupture posterior capsule during cataract surgery

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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61 participants in 4 patient groups

controls

Active Comparator group

Description:

phacoemulsification and IOL implantation

Treatment:

Procedure: phacoemulsification of the lens

diabetic without pseudoexfoliation

Active Comparator group

Description:

phacoemulsification and IOL implantation

Treatment:

Procedure: phacoemulsification of the lens

non-diabetic with pseudoexfoliation

Active Comparator group

Description:

phacoemulsification and IOL implantation

Treatment:

Procedure: phacoemulsification of the lens

diabetic with pseudoexfoliation

Active Comparator group

Description:

phacoemulsification and IOL implantation

Treatment:

Procedure: phacoemulsification of the lens