CORNEAL EPITHELIAL MAPPING IN DIABETICS

Minia University

Status: Active, not recruiting

Conditions: Cornea Epithelial Mapping

Treatments: Other: corneal imaging

Study type: Observational

Funder types: Other

Identifiers

NCT04734158

MiniaUN

Details and patient eligibility

About

The corneal epithelium is the outermost layer that covers the front of the eye; it not only functions as a barrier that blocks the passage of foreign material, but also plays an important role in maintaining high optical quality. The stem cells in the basal layer of the limbal epithelium hold a physiological significance in the renewal and metabolism of corneal epithelium, particularly under stressful situations.

Full description

The cornea in diabetic patients suffers from cellular dysfunction and dysfunctional repairal mechanisms, which include recurrent erosions, delayed wound healing, ulcers, and edema. In addition and undoubtedly related to epithelial dysfunction, alterations in epithelial basement membrane occur.

Enrollment: 153 estimated patients

Sex: All

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. The patients aged between 40- 60 years old of both genders.
2. The patients in (Group A) should be diabetics for more than 10 years and free from any other systemic diseases with diabetic macular edema (by OCT).
3. The patients in (Group B) should be diabetics for more than 10 years and free from any other systemic diseases without diabetic macular edema (by OCT).
4. The patients in (Group C) should be free of any systemic diseases and normal macular thickness (by OCT)

Exclusion criteria

1. Previous history of any intraocular surgery, intravitreal injection, laser or refractive surgery.
2. Ocular surface disorders (e.g. dry eye) or any corneal pathology.
3. Corneal scars or epithelial dystrophies.
4. Use of any topical medications.
5. Elevated IOP, pregnancy or lactation.

Trial design

153 participants in 3 patient groups

Healthy control

Treatment:

Other: corneal imaging

Diabetics with macular edema

Treatment:

Other: corneal imaging

Diabetics without macular edema

Treatment:

Other: corneal imaging