Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia (CHEETAH)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Completed

Conditions: Familial Hypercholesterolemia

Treatments: Diagnostic Test: Coronary computed tomography angiography (CCTA)

Study type: Interventional

Funder types: Other

Identifiers

NCT05352386

NL79640.018.21

Details and patient eligibility

About

This study evaluates plaque burden and characteristics in early-treated FH patients compared to late-treated FH patients and healthy individuals.

Enrollment: 135 patients

Sex: All

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosed with heterozygous familial hypercholesterolemia or non FH-control
• Adult patients between 25 and 55 years old.

Exclusion criteria

• Renal insufficiency, defined as eGFR < 30 ml/min
• Atrial fibrillation
• Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
• Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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135 participants in 3 patient groups

Patients with familial hypercholesterolemia, early treated

Other group

Treatment:

Diagnostic Test: Coronary computed tomography angiography (CCTA)

Patients without familial hypercholesterolemia, late treated

Other group

Treatment:

Diagnostic Test: Coronary computed tomography angiography (CCTA)

Healthy individuals

Other group

Treatment:

Diagnostic Test: Coronary computed tomography angiography (CCTA)