Coronary Artery Calcification Assessed on PET Scanner (PET : Positron Emission Tomography) (CALCOTEP)

Centre Hospitalier Régional d'Orléans

Status: Enrolling

Conditions: Coronary Artery Disease; Coronary Artery Calcification

Treatments: Other: Questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT06379295

CHUO-2024-05

Details and patient eligibility

About

Calcification artery calcium (CAC) scoring is a valuable tool for determining the risk of major adverse cardiac events.

It was found that CAC can be quantitatively assessed, by manual scoring or using deep-learning, on low-dose non electrocardiogram-gated, contrast-enhanced or non-enhanced computed tomography (CT-scan) performed in association of PET acquisition, with a good agreement with standard scans.

The purpose of this study is to determine the impact of a systematic coronary artery calcification evaluation in patients undergoing flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging to improve primary prevention of cardiovascular diseases.

A visual calcification artery calcium assessment will be made for each patient, dividing them into four groups: none, mild, moderate or heavy calcification artery calcium. When possible, a calcification artery calcium score will be computed.

Each patient will complete a questionnaire to collect risk factors, history of cardiovascular diseases and medications.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients referred for a 18F-FDG PT/CT imaging
• Patients aged 18 and older

Exclusion criteria

• Patients who already participated in this study (in case of follow-up PET/CT scans)
• Unusable CT scan due to CT artifacts or poor-quality images
• Patients referred for a brain 18F-FDG PET/CT imaging
• Minors,
• Protected adults
• Pregnant or breastfeeding women