Coronary Artery Disease (CAD) in Patients HIV-infected (CoroVIH)

Hôpital Européen Marseille

Status: Unknown

Conditions: HIV Infections

Treatments: Other: coronary computed tomographic angiographic (CCTA)

Study type: Observational

Funder types: Other

Identifiers

NCT04579146

2019-A00219-48

Details and patient eligibility

About

HIV-infected patients with intermediate-high risk have a high prevalence of CAD and a substantial proportion of obstructive CAD. Degree of stenosis is associated with immunoactivation (lymphocyte and monocyte) and microbial translocation

Enrollment: 60 estimated patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

HIV-infected patients >= 45 years with 2 or more CV risk factors currently on ART HIV-RNA < 50 copies >= 12 months (one blip allowed) Asymptomatic regarding cardiac symptoms (chest pain, syncope, dyspnea) Stable ART for more than 6 months

Exclusion criteria

• Sign of coronary pathology (chest pain, syncope, dyspnea).
• ATCD of allergy to IV contrast agents
• Chronic inflammatory disease other than HIV
• Subject to a measure for the protection of justice

Trial design

60 participants in 1 patient group

HIV-1 patients and treated effectively for more than 12 months

Description:

X-ray examination with contrast by a 64-slice CT coronary angiography.

Treatment:

Other: coronary computed tomographic angiographic (CCTA)