Coronary Artery Disease Management Using Multislice Computed Tomography and Magnetic Resonance Imaging (CAD-Man)

Charité University Medicine Berlin

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Procedure: CT/MR; Procedure: Catheterization

Study type: Interventional

Funder types: Other

Identifiers

NCT00844220

EA1/080/08

Details and patient eligibility

About

The primary objective of this study is to analyze the clinical value of a therapeutic management strategy based on the results of coronary CT angiography and functional MRI. The clinical value of CT and MRI will be analyzed in patients with suspected coronary artery disease.

Enrollment: 340 patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected coronary artery disease and planned conventional coronary angiography based on atypical angina pectoris

Exclusion criteria

• Known coronary artery disease
• ST elevation
• Age below 30 years
• Women of child-bearing potential without a negative pregnancy test
• Inclusion in another study
• Heart rate above 70 beats per min and contraindications to beta blockers
• Atrial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block
• Inability to hold the breath for 10 s

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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340 participants in 2 patient groups

CT/MR

Experimental group

Description:

CT/MRI-directed clinical management strategy

Treatment:

Procedure: CT/MR

Catheterization

Active Comparator group

Description:

Standard clinical management

Treatment:

Procedure: Catheterization