Coronary Artery Disease Severity in Newly Diagnosed Dysglycemia

Saud Al Babtain Cardiac Center

Status: Completed

Conditions: Coronary Artery Disease; Dysglycemia

Treatments: Radiation: Cardiac catheterization

Study type: Observational

Funder types: Other

Identifiers

NCT05210972

SBCC-IRB-2021-06

Details and patient eligibility

About

This cohort study will measure how severe is the coronary artery disease (CAD), at time of CAD diagnosis, clinically and angiographically in the different cohorts of newly diagnosed diabetes and prediabetes versus normal glycemia patients in the study center.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All adult patients with consents.
• First time diagnosis of CAD and no prior diagnosis of diabetes milletus (DM), or prediabetes.
• Coronary artery disease confirmed by invasive coronary angiography.

Exclusion criteria

1. Patients with known significant anemia, increased hemoglobin turnover, active hemoglobin drops or on erythropoietin therapy.
2. Pregnant and post-partum patients (up to 3 months post-delivery).
3. Patients with severe chronic renal failure (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.72 m2).
4. Patients on any medications with glucose lowering effects.

Trial design

150 participants in 3 patient groups

Diabetes

Description:

Patients with level of HbA1c ≥ 6.5%, or Fasting blood glucose (FBG) ≥126 mg/dL, or a random plasma glucose (RBG) ≥ 200 mg/dL in a patient with classic symptoms of hyperglycemia. In the absence of unequivocal hyperglycemia, diagnosis will be based on two abnormal test results, for FBG or RBG and HbA1c, from the same sample or in two separate test samples.

Treatment:

Radiation: Cardiac catheterization

Prediabetes

Description:

HbA1c 5.7-6.4% or FBG 110 mg/dL to 125 mg/dL The diagnosis will be based on two abnormal test results, for FBG or RBG and HbA1c, from the same sample or in two separate test samples.

Treatment:

Radiation: Cardiac catheterization

Normal glycemia

Description:

HbA1c \<5.7% and FBG 110 mg/dL

Treatment:

Radiation: Cardiac catheterization