Coronary Artery Geometry and the Severity of Coronary Atherosclerosis (GEOMETRY-CTA)

Aristotle University Of Thessaloniki

Status: Unknown

Conditions: Coronary Artery Disease; Stable Angina; Atherosclerosis; Atherosclerotic Plaque

Treatments: Diagnostic Test: CCTA

Study type: Observational

Funder types: Other

Identifiers

NCT04185493

GEOMETRY_29.01.2019.101068

Details and patient eligibility

About

The purpose of this study is to investigate the potential association of coronary artery geometry, based on coronary CT angiography (CCTA), with the complexity and the severity of coronary atherosclerosis.

Full description

The angulation of the side branch take-off has been reported to influence the severity of atherosclerosis in coronary bifurcations, as larger angles have been associated with increased plaque burden. Data from computational fluid dynamics studies have confirmed this finding by demonstrating that even in the absence of alterations in the amount of branch flow, a wide angle between the side branches intensifies flow perturbations, increases the spatial endothelial shear stress (ESS) variations in the bifurcation region and the low ESS in the lateral walls, thereby augmenting the atherosclerosis-prone environment. The magnitude of reversed flow, the extension of the recirculation zone and the duration of flow separation during the pulse cycle comprise other haemodynamic parameters which are important in atherogenesis and are amplified by an increased bifurcation angle.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients referred for cardiac CT angiography
• Patients without previous history of Coronary Artery Disease (CAD)
• Age ≥ 18 years
• Patients giving voluntary written consent to participate in the study

Exclusion criteria

• Pregnancy or breast-feeding
• Patients with serious concurrent disease and life expectancy of < 1 year
• Patients with a previous history of CAD
• Patients who refuse to give written consent for participation in the study

Trial design

100 participants in 1 patient group

CCTA Cohort

Description:

Consecutive patients with suspected coronary artery disease and low/intermediate pre-test probability

Treatment:

Diagnostic Test: CCTA