Coronary Artery Plaque Burden in Stable Angina and Non-obstructive Coronary Artery Disease

University of Bergen

Status: Active, not recruiting

Conditions: Coronary Artery Disease; Plaque, Atherosclerotic

Treatments: Diagnostic Test: Coronary artery plaque assessment by CT coronary angiography QAngio CT RE

Study type: Observational

Funder types: Other

Identifiers

NCT04009421

1573

Details and patient eligibility

About

Non-obstructive coronary artery disease (CAD), particularly common in women, has been associated with impaired quality of life and risk of recurrent hospitalizations. Several studies have also demonstrated increased risk of incident acute coronary events and mortality.

The main objective of the project is to assess the association between coronary artery plaque features by coronary CT angiography and long term prognosis in a large unselected population undergoing CT coronary angiography due to stable angina and suspected myocardial ischemia from the Norwegian Registry for Invasive Cardiology (NORIC) diagnosed with non-obstructive CAD by coronary CT angiography.

Full description

Patients with stable angina and non-obstructive coronary artery disease by CT coronary angiography will be selected from the Norwegian Registry of Invasive Cardiology (NORIC). This is a national quality control registry run and controlled by the Norwegian Institute of Public Health (www.fhi.no). All CT coronary angiograms will be reanalyzed using advanced post-processing analysis software to assess coronary artery plaque burden, distribution and composition. Through linking with the Norwegian Cardiovascular Disease Registry and the Cause of Death Registry (www.fhi.no) we will be able to assess the association between long-term prognosis (5 years) and coronary artery plaque features.

Enrollment: 1,400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable angina
• Non-obstructive coronary artery disease by CT coronary angiography defined as <50% stenosis (lumen diameter reduction)

Exclusion criteria

• Obstructive coronary artery disease
• Unstable angina
• Previous myocardial infarction, heart surgery or percutaneous coronary interventions

Trial design

1,400 participants in 1 patient group

High and low coronary artery plaque burden

Description:

Patients with high plaque burden defined as plaque in \>=4 segments of the coronary tree and low plaque burden as plaque in \<4 segments of the coronary tree assessed by postprocessing of CT coronary angiography images and cardiovascular events and mortality.

Treatment:

Diagnostic Test: Coronary artery plaque assessment by CT coronary angiography QAngio CT RE