Coronary Artery Study in Pediatric Heart Transplantation (CAS-POHT)

Arkansas Children's Hospital Research Institute

Status: Withdrawn

Conditions: Transplant Coronary Artery Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01546870

ArkansasChRI

Details and patient eligibility

About

Transplant coronary artery disease (TCAD) is a significant cause of morbidity and mortality in pediatric heart transplantation (PHT). Understanding the pathophysiology and early detection along with attempted medical management are crucial in preventing advancement of the disease and retransplantation or mortality. Coronary angiogram, although routinely used is insensitive to detect early TCAD. Measurement of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microvascular resistance (IMR) using a doppler pressure and flow intracoronary wire may be more sensitive in evaluating the integrity of coronary vasculature and thus detect pre clinical TCAD. To the best of the investigators knowledge, measurement of these parameters has not been previously reported in PHT.

Sex: All

Ages: 7 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• less than 21 years and above 7 years of age

Exclusion criteria

• clinically significant coronary artery disease on angiography and inability to undergo IVUS

Trial design

0 participants in 1 patient group

pediatric heart transplant recipients