Coronary Bypass Grafting With Minimal Extracorporeal Circulation System Versus Off-pump Coronary Surgery

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status

Completed

Conditions

Coronary Artery Disease

Treatments

Procedure: Off-pump coronary artery bypass graft

Procedure: Mini extracorporeal circulation bypass

Study type

Observational

Funder types

Other

Identifiers

NCT02118025

MECC-1 (Other Identifier)

Details and patient eligibility

About

The investigators aimed to evaluate the clinical results and the inflammatory response of the minimal extracorporeal circulation system (MECC) Compared with off-pump coronary revascularization (OPCABG).

This is a randomized and prospective study in 230 patients with indications for coronary surgery, with 113 patients in the OPCABG group and 117 in the MECC group. The endpoints were the clinical and biochemical results, intra-operative outcomes and the determination of 19 inflammatory circulating markers, 17 of them for the first time analyzed comparing both techniques.

Enrollment

230 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Indication for coronary surgery established on the basis of current published guidelines

Exclusion criteria

Documented preoperative systemic proinflammatory status and/or steroid administration within 6 months before surgery.
Coexistence of a cardiomyopathy different than coronary artery disease that precise surgical treatment.
Left ventricle ejection fraction of 40% or less.
Treatment with erythropoietin (EPO) three months before the intervention
Hematocrit less than 35% the day prior to the procedure
Redo surgery