Coronary Disease and the Effect of High-intensity Interval Training (CENIT)

Norwegian University of Science and Technology

Status: Completed

Conditions: Coronary Disease

Treatments: Other: Usual care; Behavioral: high intensity interval-based aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02494947

2015/210

Details and patient eligibility

About

The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable coronary artery disease
• will undergo cardiac catheterization
• will be treated with percutaneous coronary intervention (PCI)
• signed written informed consent
• able to execute the intervention

Exclusion criteria

• earlier bypass surgery
• known inflammatory disease other than atherosclerosis
• planned surgery within 4 months
• included in another randomized controlled study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

interval training

Experimental group

Description:

high intensity interval-based aerobic exercise

Treatment:

Other: Usual care

Behavioral: high intensity interval-based aerobic exercise

controls

Other group

Description:

usual care

Treatment:

Other: Usual care