Coronary Flow Reserve (CFR) in Cardiovascular Risk Stratification (CFR-OR)

Centre Hospitalier Régional d'Orléans

Status: Completed

Conditions: Ischemic Heart Disease; Ischemia, Myocardial

Treatments: Diagnostic Test: CZT SPECT acquisition

Study type: Interventional

Funder types: Other

Identifiers

NCT03586492

CHRO-2018-05

Details and patient eligibility

About

CFR has been studied for few years using 82 Rubidium PET (positron emission tomography) /CT. CFR has shown to be correlated with cardiovascular events occurring in the 10 following years. CFR also helps to identify multivessel coronary disease. Few studies have shown the possibility to calculate CFR during myocardial perfusion SPECT on new ultrafast CZT cameras.

Full description

Evaluate the contribution of CZT SPECT CFR in cardiovascular risk stratification: correlation with clinical scores, with calcium score, and when pathological with coronarography findings especially fractional flow reserve (FFR).

Enrollment: 137 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients referred for myocardial ischemia screening

Exclusion criteria

• Patient already suffering from coronary disease with angioplasty, bypass surgery or myocardial infarction.
• Contraindications related to the stress test:

Acute Coronary Syndrome <5 days Unstable angina Stenosis of left main artery untreated Uncontrolled severe rhythm disorders Uncontrolled heart failure

• Contraindications to dipyridamole and regadenoson:

Hypotension (systolic <90mmHg) Severe pulmonary arterial hypertension Bradycardia <40 beats / minute Sinusal Dysfunction and 2nd or 3rd degree Atrioventricular block Decompensated Heart Failure with Ejection Fraction <25% Stenosis of supra-aortic trunks unilateral> 70% or bilateral> 50% Dipyridamole and regadenoson allergy

• Patients with pacemaker, or who have had valvular surgery,
• Well-known dilated cardiopathy
• Pregnant or breastfeeding women,
• Minor people
• Persons under guardianship or under guardianship

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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137 participants in 1 patient group

Patient with myocardial ischemia

Other group

Treatment:

Diagnostic Test: CZT SPECT acquisition