Coronary Hemodynamics by Coronary Angiography (ESCARGOT)

Kangwon National University

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Drug: Hyperemic stimuli

Study type: Interventional

Funder types: Other

Identifiers

NCT04646278

B-2017-01-012-015

Details and patient eligibility

About

Study for developing techniques to evaluate coronary artery hemodynamic profiles by conventional angiography without more dedicated measuring devices.

Full description

* Methods: Compare TIMI frame count, coronary clearance frame count in baseline/hyperemic coronary angiography with FFR, CFR, IMR and derive correlation, receiver-operating characteristic curve to find new tools estimating coronary hemodynamics by conventional angiography only.

A TIMI frame count is measured by counting the angiographic image cine frames during a head of radiocontrast column runs from the entry of left anterior descending artery (LAD) to the distal end.

A coronary clearance frame count is measured by counting the angiographic image cine frames during a tail of radiocontrast column runs from the entry of LAD to the distal end.

Baseline angiography is performed without any stimulation and hyperemic angiography is performed after intracoronary injection of adenosine 300ug or nicorandiol 2mg.

Inclusion criteria

• Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography

Exclusion criteria

• ST elevation myocardial infarction
• Cardiogenic shock
• Congestive heart failure with pulmonary edema
• LVEF < 30%
• Previous history of coronary revascularization
• Chronic total occlusion
• 3 vessel disease
• Target lesion at distal segments or branches

Enrollment: 50 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography

Exclusion criteria

• ST elevation myocardial infarction
• Cardiogenic shock
• Congestive heart failure with pulmonary edema
• LVEF < 30%
• Previous history of coronary revascularization
• Chronic total occlusion
• 3 vessel disease
• Target lesion at distal segments or branches

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Hyperemic stimuli

Experimental group

Description:

Hyperemic stimuli of coronary flow by adenosine or nicorandil injection

Treatment:

Drug: Hyperemic stimuli