Coronavirus Disease 2019 (COVID-19) Study of Hospitalized Patients in Hong Kong

The Chinese University of Hong Kong

Status: Unknown

Conditions: Coronavirus Infections

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04325919

COVID-19 study 2020.076

Details and patient eligibility

About

COVID-19 may cause another world-wide epidemic. This study is divided into 2 arms: (1) Prospective longitudinal observational study involving patients with laboratory-confirmed COVID-19 and (2) Retrospective study on patients with laboratory-confirmed COVID-19.

Arm 1:

We will collect EDTA blood, stool samples, rectal swab, urine, saliva, and specimens from upper respiratory tract (nasopharyngeal aspirate or flocked swab), and lower respiratory tract (sputum or tracheal aspirate) on daily, alternate day, or weekly basis as appropriate.

Arm 2:

The remainder of specimens that were submitted for laboratory investigation as part of clinical management will be retrieved. Those specimens will only be used after all clinically indicated testing and confirmation procedures have been completed. Assistance from the Public Health Laboratory Service, Department of Health, will be invited to retrieve samples as well as participate in this study.

Patients hospitalized for pneumonia in medical wards and ICU at the Prince of Wales Hospital tested negative for COVID-19 will be recruited as controls.

Understanding the clinical, virological, microbiological and immunological profiles of this infection is urgently needed to facilitate its management and control.

Enrollment: 170 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Case are adults age ≥ 18 years old admitted to hospital with laboratory confirmed COVID-19
• Controls are patients admitted for community-acquired pneumonia

Exclusion criteria

• Patients who refuse to consent for study