Corpus Callosum Size in Patients With Pineal Cyst

M

Military University Hospital, Prague

Status

Unknown

Conditions

Corpus Callosum Atrophy
Cerebral Palsy
Pineal Gland Disorder

Treatments

Diagnostic Test: MR of the brain

Study type

Observational

Funder types

Other

Identifiers

NCT03183427
108/11-28/2017

Details and patient eligibility

About

This study aims to determine size of corpus callosum on midsagittal MR scan in patients with a pineal cyst and to compare it with the control group without a pineal cyst.

Full description

A pineal cyst (PC) is a benign affection of the pineal gland, its prevalence in population reaches 1-2 %. Etiopathogenesis of PC is unknown, several hypotheses have been proposed. One of the hypothesis consider perinatal hypoxia as a causative factor for a development of PC in later life. Ozmen et al. showed significantly higher prevalence of PC in patients with cerebral palsy (p<0.001). Bregant et al. studied presence of PC in patients that suffered from a mild to moderate perinatal hypoxia. Prevalence of PC reached 36 % in these patients and presence of PC was associated with a atrophy of the corpus callosum (p<0.005). The atrophy of the corpus callosum is considered to be a sign of a periventricular leukomalacia, i.e. an ischemic insult in a perinatal period. In the present study, we are going to compare an area of corpus callosum on a midsagittal magnetic resonance T2-weighted scan in the group of patients with PC and in the control group without PC. The goal of the study is to determine if there is a relationship between atrophy of the corpus callosum and PC. Such finding would support abovementioned theory of etiopathogenesis of PC.

Enrollment

200 estimated patients

Sex

All

Ages

18 to 99 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

3T MR examination of the brain including T2 sagittal scans

Exclusion criteria

  • other intracranial pathology discovered on the MR
  • other known neurological disease (e.g. multiple sclerosis, stroke, tumor, etc.)

Trial design

200 participants in 2 patient groups

Group of patients with pineal cyst
Description:
Group of patients with pineal cyst
Treatment:
Diagnostic Test: MR of the brain
Control group
Description:
Group of subjects without pineal cyst
Treatment:
Diagnostic Test: MR of the brain

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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