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Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT

Yonsei University logo

Yonsei University

Status

Unknown

Conditions

Myopia
Glaucoma

Study type

Observational

Funder types

Other

Identifiers

NCT00741130
3-2008-0076

Details and patient eligibility

About

Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc. In the present study, the corrected RNFL thickness by the optic nerve head configuration using the Cirrus HD OCT will be evaluated. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Full description

Finding the localized retinal nerve fiber layer (RNFL) defect and measuring the RNFL thickness are two main issues for early glaucoma detection. A recently developed imaging device, the Cirrus HD OCT, offers more detailed informations about retina architecture including optic nerve head. To calculate the RNFL thickness, the software of the Cirrus HD OCT supposes an ideal optic nerve head. However, in the cases with not ideal optic disc configuration, the measurement of the RNFL thickness is not correct. Because the measurement of the RNFL thickness is extremely sensitive to the position of measurement, patients with the tilted disc are in danger of misdiagnosis. In the present study, we want to correct the RNFL thickness measurement according to the optic nerve head configuration using the Cirrus HD OCT. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Enrollment

50 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • normal controls or glaucoma patients
  • signal intensity of the OCT image > 8
  • cooperative subjects

Exclusion criteria

  • spherical equivalent refractive errors > +4 diopters or < -4 diopters
  • significant media opacity
  • previous intraocular surgery

Trial design

50 participants in 2 patient groups

C
Description:
normal volunteers
G
Description:
glaucoma patients

Trial contacts and locations

1

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Central trial contact

Gong Je Seong, MD, PhD

Data sourced from clinicaltrials.gov

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