Correlation Analysis of Xpert Carba-R Detection of Non-colonized CRE in BALF and Rectal Swabs From Patients With LRTI

Nanjing Medical University

Status: Invitation-only

Conditions: Carbapenem-Resistant Enterobacteriaceae; Lower Respiratory Tract Infections

Study type: Observational

Funder types: Other

Identifiers

NCT06636890

2024-SR-697

Details and patient eligibility

About

Assess the correlation between Xpert Carba-R detection of carbapenemase gene types in bronchoalveolar lavage samples and rectal swab samples from non-colonized CRKP patients with lower respiratory tract infections, and evaluate the relationship between first-time lower respiratory tract infections and intestinal colonization of CRKP.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 years and above
• CRKP is cultured from lower respiratory tract specimens in 15 days
• Lower respiratory tract infection based on at least two of the followings: abnormal temperature (body temperature greater than 38.5°C or less than 36.5°C), leucocyte count abnormality (leucocyte count greater than 10*10^9/L or less than 4*10^9/L), and the presence of purulent tracheal secretions.

Exclusion criteria

• There are other bacteria that can produce carbapenemases exist in lower respiratory tract specimens
• Infected with CRE before