Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)

Ruhr University of Bochum

Status: Completed

Conditions: Healthy Subjects; Complex Regional Pain Syndrome Type I of the Upper Limb; Unilateral Limb Pain of Other Origin

Treatments: Procedure: Pressure Pain measurement

Study type: Observational

Funder types: Other

Identifiers

NCT01623141

Scinti/PressurePain2011

Details and patient eligibility

About

The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the upper limb and a non-CRPS-group. The investigators assume that there will be a significant correlation between the investigated values in the CRPS-group whereas the non-CRPS-group shows no significant correlation.

Full description

Pressure pain of the distal hand joints is a predominant symptom of CRPS. But so far, the diagnostic value of pressure pain in the diagnosis of CRPS has not been investigated. We compared the pressure pain thresholds of the carpus, metacarpophalangeal and proximal interphalangeal joints to a region of interest-based (ROI) analysis of a TBPS in patients with CRPS and patients with limb pain of other origin (non-CRPS-group).Additionally, the PPTs were established for a healthy control group to get reference data.

Enrollment: 53 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

every participant:

• aged > 18 years with written informed consent
• adequate understanding of the german language
• indication for a TPBS independent of the study

Patients with CRPS:

• patients with CRPS type 1 of the upper limb diagnosed on the basis of the budapest criteria (Harden, Bruehl et al., 2010)
• unilateral pain

Control group:

• patients with pain of the upper limbs of other origin than CRPS who underwent a TPBS
• unilateral pain

Healthy subjects:

• checked by the DFNS IMI questionnaire

Exclusion criteria

• missing informed consent
• inadequate understanding of the german language
• disease duration of more than 12 months
• other disease of the upper extremity (e.g. polyarthrosis, rheumatoid arthritis)
• pregnancy/ lactation period

Trial design

53 participants in 3 patient groups

Patients with CRPS

Description:

18 patients with unilateral CPRS of the upper limb were included to the study

Treatment:

Procedure: Pressure Pain measurement

Patients with limb pain of other origin

Description:

17 patients with unilateral upper limb pain of other origin served as control group

Treatment:

Procedure: Pressure Pain measurement

Healthy subjects

Description:

18 healthy subjects were included to establish reference data for the pressure pain thresholds

Treatment:

Procedure: Pressure Pain measurement