Correlation Between Aqueous Protein Level and Clinical Grading of Flare and Flaremetry.

The Eye Center and The Eye Foundation for Research in Ophthalmology

Status: Completed

Conditions: Uveitis

Treatments: Procedure: Paracentesis of the anterior chamber

Study type: Interventional

Funder types: Other

Identifiers

NCT01905579

TEC 123

TEC 2012-003 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to compare flaremetry readings with the protein content of the aqueous humor and the clinical grading of flare.

Full description

A total of 20 patients will be included. 10 patients with uveitis and 10 control patients scheduled for phacoemulsification. Each patient will undego complete ophthalmic examination and clinical biomicroscopic grading of the anterior chamber flare applying the SUN working group grading system. Aqueous specimens will be obtained by anterior chamber paracentesis for protein analysis. Each Patient will undego paracentesis and 0.2 ml of aqueous will be obtained. The aqueous sample will be stored at -70°C until the time of analysis for protein content. Objective assessment of flare will be done.

Enrollment: 20 patients

Sex: All

Ages: 10 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 10 patients with uveitis with cataract
• 10 patients without uveitis with cataract
• Inactive inflammation for at least 3 months

Exclusion criteria

• Infectious uveitis
• endophthalmitis
• cases with corneal scar

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

patients with uveitis

Experimental group

Description:

Paracentesis of the anterior chamber in Paients with uveitis undergoing cataract surgery

Treatment:

Procedure: Paracentesis of the anterior chamber

patients without uveitis

Experimental group

Description:

Paracentesis of the anterior chamber in patients without uveitis undergoing routine cataract surgery

Treatment:

Procedure: Paracentesis of the anterior chamber