Correlation Between Body Composition and Pathologic Grade/Prognosis in GEP-NENs: A Retrospective Study

Tongji Hospital

Status: Completed

Conditions: Neuroendocrine Tumors

Treatments: Other: body composition calculate

Study type: Observational

Funder types: Other

Identifiers

NCT06983106

TJ-IRB202411010

Details and patient eligibility

About

The goal of this observational study is to learn about the value of body composition as predictors of pathological grading and prognosis in patients with gastroenteropancreatic neuroendocrine neoplasms.

The main question it aims to answer is: Does body composition affect the pathological grading and prognosis of patients with gastroenteropancreatic neuroendocrine tumors? Participants with gastroenteropancreatic neuroendocrine neoplasms will answer questions about their physical condition during follow-up visits.

Full description

Objectives To explore the value of body composition parameters (BCPs) as predictors of pathological grading, prognosis in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).

Methods This retrospective multicenter analysis enrolled GEP-NENs patients pathologically confirmed from three institutions between 2015 and 2024. The volume of skeletal muscle and abdominal fat tissue was calculated based on CT scans at diagnosis. Univariate and multivariate logistic regression analyses were used to identify the relationships between BCPs and the pathological grade. The Kaplan-Meier method, along with the log-rank test, was employed for survival analysis. Independent prognostic factors were identified through uni- and multivariable Cox regression analyses.

Enrollment: 633 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• A confirmed diagnosis of GEP-NENs via histopathology with a WHO grading
• Available enhanced CT scans that included full abdominal imaging before surgery or biopsy

Exclusion criteria

• Therapeutic interventions before surgery or biopsy
• Poor image quality or incomplete CT images of the whole abdomen

Trial design