Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

Korea University

Status: Completed

Conditions: Atherosclerosis

Treatments: Other: Cross sectional study

Study type: Observational

Funder types: Other

Identifiers

NCT01150019

PET_Resistin

Details and patient eligibility

About

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

Enrollment: 120 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers for visiting routine medical check in our clinic

Exclusion criteria

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
• Diabetes
• Hypertension
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin

Trial design

120 participants in 2 patient groups

Obese Group

Treatment:

Other: Cross sectional study

Non Obese Group

Treatment:

Other: Cross sectional study