Correlation Between Creatine Phosphokinase and Pelvic Floor Muscle Strength in Postnatal Women

Cairo University (CU)

Status: Enrolling

Conditions: Pelvic Floor; Rupture, Old (Postpartum)

Treatments: Other: Assessment of pelvic floor muscle strength; Other: Assessment of creatine phosphokinase

Study type: Observational

Funder types: Other

Identifiers

NCT06502392

P.T.REC/012/004954

Details and patient eligibility

About

The purpose of this study is to determine the correlation between creatine phosphokinase and pelvic floor muscle strength in post-partum women.

Full description

Pelvic floor disorders (PFDs) are complex conditions affecting women's quality of life, including issues like pelvic organ prolapse, urinary incontinence, and pelvic pain. These disorders are prevalent, with 2.6-28.7% of women experiencing urinary incontinence and 20-50% suffering from pelvic organ prolapse. Accurate diagnosis requires a comprehensive understanding of pelvic musculoskeletal components and the interaction of multiple body systems.

Creatine phosphokinase (CPK) activity can be elevated in various conditions, including muscle diseases, burns, and after strenuous exercise. During childbirth, increased serum CPK levels have been observed, attributed to enzyme release from the uterus and placenta. CPK levels typically return to normal within six weeks postpartum.

To date, no study has explored the correlation between CPK levels and pelvic floor muscle strength in postnatal women. This research aims to fill this knowledge gap, potentially benefiting medical services and expanding understanding in women's health physical therapy.

Enrollment: 84 estimated patients

Sex: Female

Ages: 25 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Post-partum women who delivered vaginally.
• Their ages will range from 25 to 35 years old.
• Their body mass index (BMI) will be <30 Kg/m2.
• CPK will be measured within the first six weeks (2nd-5th weeks) after delivery for all women.

Exclusion criteria

• Any dysfunction or associated injury or any pathological conditions which may affect the result of the study as cardiac abnormalities, thyroid dysfunction recurrent urinary tract infections, uncontrolled hypertension or diabetes mellitus.
• History of pelvic inflammatory disease, myoma and tumors, pelvic infection, ovarian cyst, any gynecological disease, any hormonal abnormality and any psychological problem.
• Pelvic floor dysfunction: genital prolapse, incontinence.
• Previous surgical operations as hysterectomy.
• Inability to understand the written and verbal instructions.