Correlation Between Environmental Pollution and Gestational Diabetes Mellitus

Women's Hospital School Of Medicine Zhejiang University

Status

Enrolling

Conditions

Gestational Diabetes Mellitus

Treatments

Other: Clinical data and specimen collection

Study type

Observational

Funder types

Other

Identifiers

NCT05388721

Environment2022

Details and patient eligibility

About

Gestational diabetes mellitus (GDM) refers to the abnormal glucose metabolism index of pregnant women during pregnancy. At present, about 15% of pregnant women will develop GDM in the second and third trimester, which seriously affects the health of the pregnant woman and the fetus. However, the etiology of GDM remains unclear. Various pollutants in the environment may have a potential impact on pregnant women and fetuses. For example, previous studies have shown that exposure to atmospheric pollutants nitric oxide and organochlorine pesticides are associated with GDM. At present, we plan to further investigate the correlation between environmental pollutants and GDM.

Enrollment

2,500 estimated patients

Sex

Female

Ages

20 to 49 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Plan to complete OGTT and give birth in the research center
First trimester
Singleton pregnancy
Without diabetes before pregnancy

Exclusion criteria

Have diseases that affect metabolic function or even threaten the life of the mother and fetus before pregnancy, such as diabetes, hypertension, heart disease, liver and kidney diseases, thyroid diseases with drug, autoimmune diseases, malignant tumors, AIDS, etc.
Fetus has a known deformity or genetic defects
Incomplete clinical data
Assisted reproductive