Correlation Between Estimated Glomerular Filtration Rate(eGFR) and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

Korea University

Status: Completed

Conditions: Atherosclerosis

Treatments: Radiation: 18FDG-PET

Study type: Observational

Funder types: Other

Identifiers

NCT02394743

PET_eGRF

Details and patient eligibility

About

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Renal insufficiency is close correlation with atherosclerosis and cardiovascular mortality.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between eGFR and vascular inflammation detected by 18F FDG-PET.

Enrollment: 360 patients

Sex: All

Ages: 30+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. absence of prior cancer diagnosis or remission from cancer at the time of PET imaging and throughout the follow-up period;
2. >=30 years of age;
3. no prior history of cardiovascular disease ; and
4. absence of acute or chronic inflammatory or autoimmune disease (based on documented medical history) or use of chronic anti-inflammatory therapy.

Exclusion criteria

1. age <35 years
2. presence of chronic inflammatory disease
3. use of anti-inflammatory medications
4. presence of active malignant cancer (defined as any radiological or pathological evidence of malignant cancer disease or undergoing chemotherapy or radiation therapy within 1 year before initial PET/CT and throughout the inter-scan duration).

Trial design

360 participants in 3 patient groups

eGFR > 90

Description:

group whose eGFR is more than 90

Treatment:

Radiation: 18FDG-PET

60 < eGFR <90

Description:

group whose eGFR is between 60 and 90

Treatment:

Radiation: 18FDG-PET

eGFR < 60

Description:

group whose eGFR is less than 60

Treatment:

Radiation: 18FDG-PET