Correlation Between Expression of Hormonal Receptors, Clinical Data, and Methylation Profile in Meningiomas (MethylRH-M)

Central Hospital, Nancy, France

Status: Invitation-only

Conditions: Meningioma

Study type: Observational

Funder types: Other

Identifiers

NCT06278103

2023PI113

Details and patient eligibility

About

This research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. The underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. The main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. The secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.

Enrollment: 180 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022.

Exclusion criteria

• Patients who did not express their consent to participate in the study.
• Patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study.
• Patients with grade 1 meningiomas not selected by randomization.
• Patients withdrawing their consent.