Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting

University Hospital Ostrava

Status: Completed

Conditions: Brain Ischemia; Carotid Stenosis; Laboratory Problem

Treatments: Procedure: Carotid stenting

Study type: Observational

Funder types: Other

Identifiers

NCT02310191

UHOG-2/2012

Details and patient eligibility

About

New brain ischemic lesions are detected in about 50% of patients undergoing carotid artery stenting (CAS). The aim was to assess correlation between selected laboratory markers and occurrence of new brain infarctions after CAS.

Full description

Methods: All consecutive patients 1) with internal carotid artery stenosis >70%, 2) indicated to CAS, 3) with signed informed consent were enrolled to the prospective study during 16 months. All patients used dual antiplatelet therapy (acetylsalicylic acid [ASA] 100 mg + clopidogrel 75 mg per day) at least 7 days before CAS. Neurological examination and brain magnetic resonance imaging (MRI) were performed before and 24 hours after CAS in all patients. Venous blood samples were collected within 24 hours before CAS in all patients: hematology + reticulocytes, coagulation markers (PT, APTT, INR, Fbg, Clauss), vWF antigen, PAI-1 activity, PAI-1 polymorphism 4G/g, Multiplate (ASA and clopidogrel resistance test). Blood samples for the assessment of anti Xa activity were collected during CAS. T-test was used for statistical evaluation.

Enrollment: 81 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

patients

1. With internal carotid artery stenosis >70%
2. Indicated to CAS
3. With signed informed consent. Able to use (acetylsalicylic acid [ASA] 100 mg + clopidogrel 75 mg per day) at least 7 days before CAS

Exclusion criteria

• Contraindication for magnetic resonance imaging

Trial design

81 participants in 1 patient group

Stenting

Description:

Carotid stenting

Treatment:

Procedure: Carotid stenting