Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy

Peking University

Status: Enrolling

Conditions: Cancer Therapy-related Cardiovascular Toxicity

Treatments: Drug: Antitumor drugs

Study type: Observational

Funder types: Other

Identifiers

NCT05728788

M2021598

Details and patient eligibility

About

The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection.

Full description

This is a monocentric prospective cohort study in which 50 patients treated for malignant tumors will be included. All participants will be followed for 6 months after the initiation of oncology drug therapy. Echocardiography and 2D speckle tracking will be performed and stool and blood samples will be tested before treatment initiation and at 3 and 6 months after initiation.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• With malignant tumors
• Will receive antitumor drugs
• Could receive regular follow-up for 6 months
• Written informed consent

Exclusion criteria

• Satisfactory echocardiographic images could not be obtained
• Cardiomyopathy
• Coronary artery disease
• Heart failure
• Arrhythmia requiring intervention
• Moderate or severe valvular disease
• Acute myocarditis
• Refractory hypertension
• Participating in other studies of drug intervention

Trial design

50 participants in 1 patient group

Patients treated with antineoplastic agents

Description:

50 patients treated with antineoplastic agents will be enrolled.

Treatment:

Drug: Antitumor drugs