Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma

Benha University

Status: Completed

Conditions: Open Angle Glaucoma

Treatments: Diagnostic Test: Optical Coherence Tomography- Angiography; Diagnostic Test: Photopic negative response

Study type: Observational

Funder types: Other

Identifiers

NCT05104294

RC-9-11-01

Details and patient eligibility

About

Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.

Full description

Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.

OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.

Enrollment: 76 patients

Sex: All

Ages: 35 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age of 30 years or older for both control and glaucoma groups.
• Spherical equivalent (SE) between -2 and +2 D.
• No history of previous eye surgery, trauma, or systemic diseases.

Exclusion criteria

• Spherical equivalent greater than +/- 2.00 diopters (D).
• Media opacity as (cataract or corneal scar).
• Any history of ocular surgeries or trauma.
• Optic nerve anomaly or other retinal diseases.
• Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).

Trial design

76 participants in 3 patient groups

mild Primary Open Angle Glaucoma group (Group I)

Description:

28 eyes of 16 patients with mild primary open angle glaucoma as group I.

Treatment:

Diagnostic Test: Photopic negative response

Diagnostic Test: Optical Coherence Tomography- Angiography

moderate to severe Primary Open Angle Glaucoma group (Group II)

Description:

44 eyes of 24 patients with moderate to severe primary open angle glaucoma as group II.

Treatment:

Diagnostic Test: Photopic negative response

Diagnostic Test: Optical Coherence Tomography- Angiography

Control Group

Description:

80 eyes of 40 healthy subjects as control group.

Treatment:

Diagnostic Test: Photopic negative response

Diagnostic Test: Optical Coherence Tomography- Angiography