Correlation Between Oxidative Stress Status and COVID-19 Severity

Shahid Beheshti University of Medical Sciences

Status: Completed

Conditions: Oxidative Stress

Treatments: Diagnostic Test: Oxidative Stress ELISA Kit

Study type: Observational

Funder types: Other

Identifiers

NCT04375137

SBMU.12543

Details and patient eligibility

About

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Full description

Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be checked by ELISA tests and compared between these two groups and healthy controls.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• more than 18 years old
• positive RT-PCR COVID-19
• compatible lung CT with COVID-19

Exclusion criteria

• not signing informed consent
• using antioxidants
• using statins

Trial design

90 participants in 3 patient groups

Severe COVID

Description:

patients with positive PCR or compatible CT admitted in ICU or intubated

Treatment:

Diagnostic Test: Oxidative Stress ELISA Kit

Non-severe COVID-19

Description:

patients with positive PCR or compatible CT admitted in ward without hypoxia

Treatment:

Diagnostic Test: Oxidative Stress ELISA Kit

Healthy Controls

Description:

Healthy controls with negative IgM/IgG for COVID-19

Treatment:

Diagnostic Test: Oxidative Stress ELISA Kit