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Correlation Between Oxidative Stress Status and COVID-19 Severity

S

Shahid Beheshti University of Medical Sciences

Status

Completed

Conditions

Oxidative Stress

Treatments

Diagnostic Test: Oxidative Stress ELISA Kit

Study type

Observational

Funder types

Other

Identifiers

NCT04375137
SBMU.12543

Details and patient eligibility

About

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Full description

Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be checked by ELISA tests and compared between these two groups and healthy controls.

Enrollment

90 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • more than 18 years old
  • positive RT-PCR COVID-19
  • compatible lung CT with COVID-19

Exclusion criteria

  • not signing informed consent
  • using antioxidants
  • using statins

Trial design

90 participants in 3 patient groups

Severe COVID
Description:
patients with positive PCR or compatible CT admitted in ICU or intubated
Treatment:
Diagnostic Test: Oxidative Stress ELISA Kit
Non-severe COVID-19
Description:
patients with positive PCR or compatible CT admitted in ward without hypoxia
Treatment:
Diagnostic Test: Oxidative Stress ELISA Kit
Healthy Controls
Description:
Healthy controls with negative IgM/IgG for COVID-19
Treatment:
Diagnostic Test: Oxidative Stress ELISA Kit

Trial contacts and locations

1

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Central trial contact

Nooshin Dalili

Data sourced from clinicaltrials.gov

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