Correlation Between PET and Advanced MRI in Multiple Sclerosis

University of British Columbia

Status: Completed

Conditions: Multiple Sclerosis

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02869360

CNS-2016-293

Details and patient eligibility

About

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific.

This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Enrollment: 14 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria.
• Aged 18 to 60
• High or mixed affinity binder to rs6971 TSPO polymorphism

Exclusion criteria

• Pregnant or breastfeeding
• Suffering from an unstable medical condition
• Have a neurological or ocular disorder other than MS
• Any contra-indications to MRI

Trial design

14 participants in 2 patient groups

Multiple Sclerosis (MS) patients

Description:

4 Secondary Progressive MS patients on no disease modifying therapy 4 Primary Progressive MS patients on no disease modifying therapy 4 Relapsing-Remitting MS patients on no disease modifying therapy 4 Relapsing-Remitting MS patients on Glatiramer Acetate 40 mg three times a week

Healthy Controls

Description:

4 Healthy volunteers aged between 18-60 years of age