Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

Xuzhou Medical University

Status: Unknown

Conditions: Postoperative Cognitive Dysfunction

Treatments: Diagnostic Test: Neuropsychology test

Study type: Observational

Funder types: Other

Identifiers

NCT03703973

POCDLTL

Details and patient eligibility

About

To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Enrollment: 1,000 estimated patients

Sex: All

Ages: 60 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-cardiac surgery patients;

  • Age is greater than or equal to 65 years old;

    • Han Nationality, mother tongue is chinese;

      ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

      ⑤The Geriatric Depression Scale (GDS) grade 1 or 2;

      ⑥The important function without serious heart, brain, liver, kidney, lung and other organs;

      • The ASA class I or II;

        • The people signed informed consent.

Exclusion criteria

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;

  • Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

Trial design

1,000 participants in 2 patient groups

study group

Description:

1000 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\]. We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.We also measure their preoperative leukocyte telomere length.

Treatment:

Diagnostic Test: Neuropsychology test

control group

Description:

We enroll 50 healthy volunteers and do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test at 1 day (baseline), 1 week, 3 months, 1 year and 3 years without safety issue.

Treatment:

Diagnostic Test: Neuropsychology test