Correlation Between SFRP1 and Colorectal Cancer and Adenoma

Xijing Hospital of Digestive Diseases

Status: Unknown

Conditions: Early Diagnosis of Colorectal Cancer and Adenoma

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05204433

XJLJ-Fecal-adenoma

Details and patient eligibility

About

In summary, our study demonstrated the methylation sites of SFRP1 gene promoter in patients with colorectal cancer and adenoma and found SFRP1_16_17_18 CpG site was good performance as a diagnostic marker of colorectal cancer.

Enrollment: 220 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• consecutive adult patients undergoing an outpatient endoscopy and histopathologically diagnosed as colorectal cancer or adenoma. Also, healthy individuals were invited to be enrolled.

Exclusion criteria

• Lynch syndrome
• Familial adenomatous polyposis
• MUTYH associated polyposis
• Peutz-Jeghers syndrome
• Juvenile polyposis syndrome
• Serrated polyposis syndrome

Trial design

220 participants in 4 patient groups

normal control

Description:

healthy volunteers

Treatment:

Other: no intervention

adenoma

Description:

pathologically reported colorectal adenoma

Treatment:

Other: no intervention

colorectcal cancer

Description:

pathologically reported colon cancers

Treatment:

Other: no intervention

High risk group

Description:

pathologically reported inflammatory bowel diseases