Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer

Mass General Brigham

Status

Completed

Conditions

Squamous Cell Carcinoma

Skin Cancer

Basal Cell Carcinoma

Study type

Observational

Funder types

Other

Industry

Identifiers

NCT00836342

2008-P-002240

Details and patient eligibility

About

The purpose of this study is to determine the difference of skin carotenoid levels between subjects with previous squamous cell carcinomas (SCC), subjects with previous basal cell carcinomas (BCC) and a control group.

Full description

There has been experimental and clinical research evaluating association of different carotenoids and incidence of malignancies, including Non- Melanoma Skin Cancer (NMSC). An easy and inexpensive way to determine which subjects would benefit from supplementation with carotenoids or retinoids could be the measurement of skin carotenoid levels.The least invasive way to perform it is through Raman spectroscopy which is a technique that uses a laser light that can be used to quantify carotenoids on the skin. We will compare the skin carotenoid levels of subjects with previous history of SCC or BCC and subjects without history of previous NMSC.

Enrollment

81 patients

Sex

All

Ages

50 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Subjects between 50 and 75 years old without history of previous SCC or BCC.
Fitzpatrick skin types I-IV.
Willing and able to understand and sign informed consent.
Able to complete study and comply with study procedures

Exclusion criteria

Regular ingestion of supplements containing carotenoids or vitamin A in the past 4 weeks.
Use of topical retinoids in the past 4 weeks.
Treatment with systemic retinoids in the past 6 months.
Dermatologic conditions that require the use of interfering topical or systemic therapy or that might interfere with study assessments such as, but not limited to, palmar psoriasis, hand dermatitis or palmo-plantar keratoderma.
Previous history of psoriasis.
Clinically significant abnormal findings or conditions, which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.
Subjects who are known to be pregnant or planning a pregnancy.